NMN (Nicotinamide Mononucleotide): Advantages, Side Effects, and Dosage

If you’re interested in aging and longevity innovations, you may well have heard of NMN, which stands for nicotinamide mononucleotide.

It’s a molecule your physique makes naturally, but some men and women also take it as a supplement. Scientists, such as Harvard University professor and longevity expert David Sinclair, are at the moment seeking into its promising possible benefits for several distinct locations of well being, including:

longevity
diabetes
liver situations
brain wellness
heart wellness
exercise coaching
sleep
Investigation on the effects of NMN supplements is still emerging, and additional investigation is needed.

We’ve partnered with Wonderfeel®, a bioscience and wellness-tech enterprise based in San Francisco, California, to bring you a primer on NMN and the research readily available so far on its prospective rewards, optimal dosage, side effects, and safety.

What is nicotinamide mononucleotide (NMN)?
Put merely, NMN is a naturally occurring molecule that assists power your physique.

NMN is a form of molecule named a nucleotide. Nucleotides play lots of roles in your body, such as as the creating blocks of DNA.

Within your cells, NMN is converted into one more molecule recognized as nicotinamide adenine dinucleotide (NAD). Your body demands NAD for a assortment of functions involved in metabolism and power production.

You could possibly think of NMN as raw material and NAD as the refined version that your physique can essentially use.

The amount of NAD your body can make depends on the amount of NMN accessible in your physique.

Rewards of NMN
All the cells in your body use NAD and thus need NMN, its precursor, to function appropriately. NAD helps cells regulate a quantity of critical functions that support maintain your cells operating smoothly, including:

energy metabolism
DNA repair
gene expression
cellular strain responses
It’s essential that your cells have plenty of NMN to produce enough NAD to help these functions.

nmn decline more than time, and, as a outcome, your levels of NAD decline, as well. This could contribute to some of the wellness effects you may experience throughout aging.

For instance, researchTrusted Supply has shown that people today with distinctive age-related circumstances, like diabetes and liver diseases, may well have lower levels of NMN and NAD.

Test-tube and animal studiesTrusted Supply also recommend that NMN may well play a part in other aspects of aging, like heart and brain well being.

NMN vs. NR
If you’ve heard of NMN, you may well have also heard of nicotinamide riboside (NR). NR is a different molecule comparable to NMN that individuals also take as a supplement for healthier aging.

EvidenceTrusted Supply suggests that the physique converts NR into NMN, which then is converted into NAD.

Potential advantages of NAD
Since taking NMN may well assist your body make additional NAD, it is also crucial to look at the study behind the added benefits of NAD. Studies investigating NAD shed light on its prospective advantages:

It may well boost longevity. In your cells, NAD activates a group of proteins called sirtuins, which support repair your DNA. The activity of sirtuins is linked to longevity. On the flip side, low-NAD levels are linked with age-related illnesses.
It may possibly have protective effects on the brain. NAD is thought to modulate the production of a protein that helps guard cells against impairment of mitochondrial function and oxidative tension. These cellular stressors are related to some neurological ailments, which includes Alzheimer’s illness.
It could enable lower heart disease danger. ResearchTrusted Supply in mice has found that high NAD levels in the blood reversed age-related arterial harm, which could assist guard against heart illness.
It may perhaps safeguard against cancer. Elevated NAD levels may support protect cells against oxidative strain and DNA damage, which are associated with cancer development.
It may well aid with jet lag. ResearchTrusted Supply suggests NAD may assistance adjust your internal clock, potentially assisting ease jet lag or other circadian rhythm issues.
It could aid aging muscle tissues. StudiesTrusted Source in older mice have shown that higher blood NAD levels helped improve muscle function, strength, and endurance in older mice.
It is important to note that these advantages had been located for NAD, not for NMN specifically. Much more research on the advantages of NMN and NAD is required.

Recent research has found that taking NAD as a supplement doesn’t lead to the same possible positive aspects — but taking NMN can.

“The real breakthrough that occurred not too long ago is our understanding of how to get NAD levels closer to these of our youth,” says Professor Andrew Salzman, MD, a Harvard Medical School alumni and a prominent drug inventor who’s top NAD and NMN investigation at Wonderfeel®.

“We now know that it can’t be done by delivering NAD either orally or by IV — since NAD has no mechanism for getting into the cell.

“However, it can be accomplished by delivering the beginning material for NAD, which is NMN. Cells have evolved a receptor for NMN — it’s a special protein on the surface of the cell which attaches to NMN and shuttles it into the cell. As soon as inside, NMN is converted by cellular enzymes to produce NAD.”